The No. 16 Notre Dame Fighting Irish (3-1) and No. 15 Louisville Cardinals (3-0) will battle at Notre Dame Stadium in South Bend, Indiana. Below, we outline the odds and best bets for you.

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When and Where is Notre Dame vs. Louisville?

• Date: Saturday, September 28, 2024
• Time: 3:30 p.m. ET
• TV Channel: Peacock
• City: South Bend, Indiana
• Venue: Notre Dame Stadium

Notre Dame vs. Louisville Prediction & Moneyline Pick

• Prediction: Notre Dame 28, Louisville 22
• Notre Dame is -243 on the moneyline, and Louisville is +197.
• Notre Dame has won 66.7% of the games this season when it was the moneyline favorite (2-1).
• When playing as a moneyline favorite with odds of -243 or shorter, the Fighting Irish have a 2-1 record (winning 66.7% of their games).
• This is the first time Louisville will play as an underdog this season.
• The Cardinals have not entered a game this season as a bigger underdog on the moneyline than the +197 odds on them winning this game.
• Based on this game’s moneyline, the Fighting Irish’s implied win probability is 70.8%.

Make your moneyline wager right now at BetMGM.

Against the Spread Pick

• Pick ATS:

  Louisville (+6.5)
  

• So far this season Notre Dame has two victories against the spread.
• The Fighting Irish have covered the spread once this season when favored by 6.5 points or more (in three chances).
• Thus far in 2024 Louisville has two wins against the spread.

You can place your bet against the spread at BetMGM.

Best Over/Under Pick

• Pick OU: Over (45)
• Notre Dame and its opponents have combined to go over Saturday’s over/under of 45 points once this season.
• The over/under for the contest of 45 is 35.1 points fewer than the combined points per game averages for Notre Dame (32.8 points per game) and Louisville (47.3 points per game).

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Key Stats Splits

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