Our computer model projects a victory for the Buffalo Bills when they meet the Indianapolis Colts at Lucas Oil Stadium on Sunday, Nov. 10 at 1 p.m. ET — for more information regarding the spread, over/under and final score, continue reading.

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The Bills are averaging 335.2 yards per game offensively this year (16th in NFL), and they are giving up 333.3 yards per game (17th) on defense. The Colts are compiling 20.9 points per contest on offense this season (22nd-ranked). Meanwhile, they are surrendering 21.4 points per game (12th-ranked) on defense.

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Colts vs. Bills Predictions and Picks

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Colts Betting Info

• The Colts have a 37.0% chance to win this game based on the implied probability of the moneyline.
• Indianapolis has compiled a 7-2-0 record against the spread this season.
• The Colts have covered the spread once this year (1-1 ATS) when playing as at least 4-point underdogs.
• In Indianapolis’ nine contests this season, the combined scoring has gone over the point total three times.
• Colts games average 44.2 total points (postseason included), 2.3 fewer than the total for this matchup.

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Bills Betting Info

• Based on this game’s moneyline, the Bills have an implied win probability of 67.7%.
• Buffalo has covered the spread five times in nine games this season.
• The Bills have covered the spread twice this season (2-2 ATS) when playing as at least 4-point favorites.
• Buffalo games have hit the over five out of nine times this season.
• The over/under for this game is 46.5 points, 0.7 more than the average point total for Bills games this season.

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Colts vs. Bills 2024 Scoring Insights

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