The No. 16 Notre Dame Fighting Irish are expected to come out on top in their matchup versus the No. 15 Louisville Cardinals at 3:30 p.m. ET on Saturday, Sept. 28, according to our computer model. If you’re wanting additional projections on the final score, spread, and point total, we’ve got you covered below.

Watch college football live without cable. Stream ACC, SEC, ESPN and more with Fubo. What is Fubo? Fubo is a streaming service that gives you access to your favorite live sports and shows on demand. Start your risk free trial today and start watching college football games now.

Notre Dame vs. Louisville Predictions and Picks

Bet on this game at BetMGM

Notre Dame Betting Info (2024)

Make smart decisions. Use those stats when making your college football picks and place your bet on BetMGM.

• The Fighting Irish have a 71.9% chance to win this matchup based on the moneyline’s implied probability.
• The Fighting Irish have posted two wins against the spread this season.
• Notre Dame has 1-2 ATS when playing as at least 7-point favorites.
• One of the Fighting Irish’s four games this season has hit the over.
• The average total for Notre Dame games this season has been 46.1, 0.1 points higher than the total for this game.

Louisville Betting Info (2024)

• Sportsbooks have implied with the moneyline set for this matchup that the Cardinals have a 32.6% chance to win.
• The Cardinals have covered every spread they have faced this year (2-0-0).
• Out of Cardinals two games with a set total, one has hit the over (50%).
• The average over/under in Louisville games this year is 10.5 more points than the point total of 46 for this outing.

See some numbers you like? Make your college football bets now at BetMGM.

Fighting Irish vs. Cardinals 2024 Scoring Averages

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.