Our computer model projects a victory for the Arizona Cardinals when they play the Detroit Lions at State Farm Stadium on Sunday, Sept. 22 at 4:25 p.m. ET — for more information regarding the spread, over/under and final score, see below.

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The Lions are putting up 21 points per game on offense (16th in NFL), and they rank 13th defensively with 20 points allowed per game. The Cardinals rank seventh with 379.5 total yards per contest on offense, and they rank 13th with 298.5 total yards given up per game on defense.

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Lions vs. Cardinals Predictions and Picks

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Lions Betting Info

• The Lions have an implied moneyline win probability of 60.0% in this matchup.
• Detroit has a record of 1-1-0 against the spread this season.
• The Lions have been favored by 3 points or more two times this season, and covered the spread in one of those contests.
• Detroit games have not hit the over yet this season.
• The point total average for Lions games this season is 52.5, 1.0 point higher than the over/under for this matchup.

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Cardinals Betting Info

• The moneyline for this contest implies a 44.4% chance of a victory for the Cardinals.
• Arizona has covered twice in two chances against the spread this year.
• The Cardinals have been an underdog by 3 points or more once this season, and covered the spread.
• Each Arizona game has gone over the point total this season.
• Cardinals games average 46.8 total points, 4.7 fewer than the total for this matchup.

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Lions vs. Cardinals 2024 Scoring Insights

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