After analyzing the 16 games on the Week 2 slate in the NFL, our best against-the-spread selection is Giants +1.5. For more suggestions, which could lead to parlay possibilities, scroll down.

NFL Picks Against the Spread – Week 2

Jump to Matchup:

Pick: Giants +1.5 vs. Commanders

• Matchup: New York Giants at Washington Commanders
• Projected Winner & Margin: Giants by 11.0 points (Bet on this game at BetMGM)
• Spread: Commanders -1.5
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Rams +1.5 vs. Cardinals

• Matchup: Los Angeles Rams at Arizona Cardinals
• Projected Winner & Margin: Rams by 11.0 points (Bet on this game at BetMGM)
• Spread: Cardinals -1.5
• Time: 4:05 PM ET
• Date: Sept. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Dolphins -2.5 vs. Bills

• Matchup: Buffalo Bills at Miami Dolphins
• Projected Winner & Margin: Dolphins by 3.0 points (Bet on this game at BetMGM)
• Spread: Dolphins -2.5
• Time: 8:15 PM ET
• Date: Sept. 12
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Browns +3 vs. Jaguars

• Matchup: Cleveland Browns at Jacksonville Jaguars
• Projected Winner & Margin: Browns by 4.0 points (Bet on this game at BetMGM)
• Spread: Jaguars -3
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Patriots +3.5 vs. Seahawks

• Matchup: Seattle Seahawks at New England Patriots
• Projected Winner & Margin: Patriots by 13.0 points (Bet on this game at BetMGM)
• Spread: Seahawks -3.5
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Colts -3.5 vs. Packers

• Matchup: Indianapolis Colts at Green Bay Packers
• Projected Winner & Margin: Colts by 4.0 points (Bet on this game at BetMGM)
• Spread: Colts -3.5
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Titans +3.5 vs. Jets

• Matchup: New York Jets at Tennessee Titans
• Projected Winner & Margin: Titans by 6.0 points (Bet on this game at BetMGM)
• Spread: Jets -3.5
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Steelers -3.5 vs. Broncos

• Matchup: Pittsburgh Steelers at Denver Broncos
• Projected Winner & Margin: Steelers by 15.0 points (Bet on this game at BetMGM)
• Spread: Steelers -3.5
• Time: 4:25 PM ET
• Date: Sept. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Vikings +6 vs. 49ers

• Matchup: San Francisco 49ers at Minnesota Vikings
• Projected Winner & Margin: Vikings by 28.0 points (Bet on this game at BetMGM)
• Spread: 49ers -6
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bengals +6 vs. Chiefs

• Matchup: Cincinnati Bengals at Kansas City Chiefs
• Projected Winner & Margin: Chiefs by 3.0 points (Bet on this game at BetMGM)
• Spread: Chiefs -6
• Time: 4:25 PM ET
• Date: Sept. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Cowboys -6.5 vs. Saints

• Matchup: New Orleans Saints at Dallas Cowboys
• Projected Winner & Margin: Cowboys by 22.0 points (Bet on this game at BetMGM)
• Spread: Cowboys -6.5
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Chargers -6.5 vs. Panthers

• Matchup: Los Angeles Chargers at Carolina Panthers
• Projected Winner & Margin: Chargers by 23.2 points (Bet on this game at BetMGM)
• Spread: Chargers -6.5
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Falcons +6.5 vs. Eagles

• Matchup: Atlanta Falcons at Philadelphia Eagles
• Projected Winner & Margin: Eagles by 3.0 points (Bet on this game at BetMGM)
• Spread: Eagles -6.5
• Time: 8:15 PM ET
• Date: Sept. 16
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Buccaneers +7 vs. Lions

• Matchup: Tampa Bay Buccaneers at Detroit Lions
• Projected Winner & Margin: Lions by 3.0 points (Bet on this game at BetMGM)
• Spread: Lions -7
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Texans -7 vs. Bears

• Matchup: Chicago Bears at Houston Texans
• Projected Winner & Margin: Texans by 13.0 points (Bet on this game at BetMGM)
• Spread: Texans -7
• Time: 8:20 PM ET
• Date: Sept. 15
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Raiders +9.5 vs. Ravens

• Matchup: Las Vegas Raiders at Baltimore Ravens
• Projected Winner & Margin: Ravens by 5.0 points (Bet on this game at BetMGM)
• Spread: Ravens -9.5
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

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